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HB22.7 happens to be getting prepared for use in individual patients in anticipation of clinical trials. Although the researchers initially thought that CD22 was expressed on B cells uniquely, they uncovered serendipitously that it also appears on lung cancer cells, although not on healthful cells in the lung. The investigators discovered CD22 in seven of the eight cell lines evaluated, which included the major lung cancer subtypes of adenocarcinoma, squamous cell, bronchoalveolar and carcinoid, however, not the epidermoid subtype. The authors also examined publicly obtainable databases and discovered that other lung cancers cell lines also expressed CD22. Our observation that CD22 is normally expressed on lung cancers cells is a very exciting discovery, especially since we have created a monoclonal antibody that targets this proteins already, said Robert O'Donnell, professor of oncology and hematology in the UC Davis Division of Internal Medication and co-principal investigator of the study.